Compared with the NC group, intraperitoneal injection of LPS obviously elevated the hepatic TNF-α, IL-1β, IL-17, and LPS levels (p < 0.05) and obviously reduced the hepatic IL-10 and TGF-β levels (p < 0.05), implying the ALI model were successfully established. The gene discussed is IL1B; the disease is acute respiratory distress syndrome.