In 2016, Agamia et al. found increased serum IGF-1 concentrations, higher cytoplasmic expression of FoxO1, and more intense cytoplasmic and nuclear expression of mTOR in acne patients than in healthy controls, and an excessive consumption of a high-glycemic-load diet was associated with higher serum levels of IGF-1 and cytoplasmic expression of FoxO1 and mTOR [95]. Here, IGF1 is linked to acne.