Navarini et al. compared 1893 severe cases of acne and 5132 controls from the United Kingdom in 2014, and found that there was an association between acne and genes related to the transforming growth factor receptor (TGF)-β signaling pathway, such as OVOL1, FST, and TGFβ2 [53]. The gene discussed is TGFB2; the disease is acne.