CRP and Increased total leukocyte count: Besides, laboratory studies have confirmed that those children show different grades of inflammation, characterized by leukocytosis (an excess of leukocytes in the blood), elevated erythrocyte sedimentation rate, high blood levels of C-reactive protein (CRP) (a marker of an acute phase of inflammation), hypoalbuminemia, and anemia (which could be normocytic due to chronic disease, microcytic due to iron deficiency, or more frequently combined) [13,14].