Other important in vivo study in SARS-CoV-2 infected hamsters showed that despite no effects in the reduction of viral load in the respiratory tracts, IVM reduced the IL-6 and IL-10 ratio and induced the polarization of macrophages towards a M2 phenotype that favored a beneficial anti-inflammatory response, inferring a potential positive implication of IVM in the clinical condition of COVID-19 patients (Figure 2) [222]. Here, IL6 is linked to COVID-19.