The results of the study, which included 3128 Han Chinese individuals divided into five groups—healthy subjects, patients with chronic hepatitis B, patients with liver cirrhosis, patients with hepatocellular carcinoma, and patients with natural clearance—showed that cytochrome B-245 alpha chain (CYBA)-rs4673AG and glutamate–cysteine ligase modifier subunit (GCLM)-rs41303970A were associated with HBV-induced liver disease, while neutrophil cytosolic factor 4 (NCF4)-rs1883112G allele and NADPH oxidase 4 (Nox4)-rs1836882 TC were encountered more frequently in healthy controls [69]. This evidence concerns the gene NOX4 and chronic hepatitis B virus infection.