Thus, intestinal FXR antagonists are considered for the treatment of metabolic diseases: the glycine-beta-muricholic acid (namely, a tauro-beta-muricholic acid derivative) is used in experimental models of NAFLD, producing a reduction in obesity, insulin resistance, and liver fibrosis/inflammation grading [70,71,72]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.