Inflammation causes an increase in the production of pro-inflammatory molecules such as cytokines, reactive oxygen species (ROS), cyclooxygenase (COX)-2, transcription factors such as NF-κB, protein kinases B, activator protein 1(AP-1) and the signal transducer and activator of transcription 3(STAT3), leading to the initiation and development of cancer [80]. The gene discussed is JUN; the disease is cancer.