PPARGC1A and acute kidney injury: Curcumin administered orally in wistar rats at 400 mg/kg/day (with AKI via a dose of potassium dichromate) could preserve mitochondrial bioenergetics by increasing the expression of mitochondrial transcription factor A and bring peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) back to a normal level [186].