AFP and hepatocellular carcinoma: As shown in Figure 9 and Table 7, the combination of the metabolite classifier and AFP exhibited much better diagnostic performance than AFP alone in differentiating, from T2DM patients, T2DM(+) HCC patients (AUC: 0.97 vs. 0.76) or T2DM(+) CRC&PC&GC patients (AUC: 0.96 vs. 0.79).