PLEK and Obesity: Interestingly, multiple SNPs, the locus of the gene encoding pleckstrin and the Sec7 domain containing 3 (PSD3), which controls the level of a carnitine in our study, have been consistently associated with triglycerides and cholesterol levels as well as type 2 diabetes and obesity [28], and their downregulation results in reduced hepatic lipids in vitro and protects against fatty liver in vivo in mice [29].