As a proinflammatory cytokine, IL-1β plays a critical role in the pathogenesis of glomerulonephritis, including immune complex glomerulonephritis, nephrotoxic serum nephritis, IgA nephritis, progressive crescentic glomerulonephritis, and lupus nephritis [43,44,45,46,47,48]. This evidence concerns the gene IL1B and lupus nephritis.