Further, the differential expression of miR-143 is associated with HCC, downregulating the expression levels of the Toll-like receptor 2 (TLR2), nuclear factor-kappa B (NF-κB), and matrix metallopeptidase 2 and 9 (MMP-2 and MMP-9) [44]. The gene discussed is MMP2; the disease is hepatocellular carcinoma.