Our present Western blot analysis demonstrated that PCSK7 inhibition by miR-125a-5p reduced the shedding of hTfR1, suggesting that miR-125a-5p could reduce the enzymatic function of PC7 and inhibit the shedding of hTfR1 and could find applications in the treatment of hereditary hemochromatosis. Here, PCSK7 is linked to hereditary hemochromatosis.