LOX and autism: Besides its antioxidant effects, vitamin E can modulate enzymes, signal transduction pathways, and transcription factors associated with the inflammatory response, such as the NF-kappa B pathway of activated mononuclear cells, and the LOX-dependent and COX-dependent pathways of arachidonic acid oxidation to generate inflammatory and vasoactive eicosanoids, which are lipid mediators related to the neurotoxicity of PPA and pathology of autism [51].