With regard to TNF-α pathway, IL-6 and NKFB have been found to have a significant prognostic role in a study on 43 patients with SSNHL compared with 10 patients with non-idiopathic SSNHL (Meniere’s disease, perilymph fistula, and bilateral progressive sensorineural hearing loss) [19]. This evidence concerns the gene TNF and Progressive sensorineural hearing impairment.