The role of IL-6 in inflammation and pathophysiology of DR was also indicated by Chen et al. who found that high levels of IL-6, its soluble receptor (sIL-6R) and soluble gp130 (sgp130) in both serum and AH in patients with DR [26] are associated with longer DM duration, fasting blood sugar and HbA1c. This evidence concerns the gene IL6R and diabetes mellitus.