For example, ATM regulates radiation-induced autophagy through the mTOR pathway [64,65], MAPK14 pathway [66], JNK pathway [67], and PI3KIII pathway [68], and complete lack of ATM function results in the failure of autophagy induction in tumor cells [68,69,70] or switches the cell stress response to senescence [71]. The gene discussed is MAPK8; the disease is neoplasm.