CASP3 and coronary artery disorder: In a swine phlegm and blood stasis type coronary heart disease model, Xue-Fu-Zhu-Yu-Tang combined with Gua-Lou-Xie-Bai-Ban-Xia-Tang was shown to have significant protective effects against myocardial apoptosis, upregulate Bcl-2 protein expression, and downregulate Bax, Caspase-3, and Caspase-9 protein expression [34].