Results have shown that the green-synthetized Pg-AgNPs_S2 (obtained at 60 °C, using AgNO3 of 5 M) induced a substantial decrease in tumor cell viability in a dose-dependent manner with an IC50 ranging from 5.03 to 5.07 μg/mL on A549 cell line and 3.24 to 4.93 μg/mL on MCF7 cell line. This evidence concerns the gene JUP and neoplasm.