Plat (h2 = 0.70) represents the Plasminogen Activator, which is a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme [45]; its role has been highlighted to be linked with the maintenance of axonal integrity [45], as its decreased activity impairs the capacity of clearing fibrinogen deposits at sites of blood–brain barrier breakdown, demyelinated axons, and inflammatory MS lesions, therefore promoting further axonal injury [46,47]. This evidence concerns the gene PLAT and myeloid sarcoma.