SOD1 and neurodegenerative disease: For these reasons, oxidative stress has been strongly linked to the pathogenesis of myelin destruction in MS and in other neurodegenerative diseases [52]; in fact, an impaired decreased Sod1 secretion has been related, due to decreasing antioxidant defenses, to neurodegenerative diseases, e.g., Amyotrophic Lateral Sclerosis (ALS) [51] and RR-MS [52].