Irradiation of p53 wild-type non-small cell lung cancer cells in vitro may induce an senescence-associated secretory phenotype (SASP), which expressed CD63 and generates extracellular vesicles with DNA:RNA hybrids and LINE-1 retrotransposons, causing an abscopal phenomenon [181]. The gene discussed is TP53; the disease is non-small cell lung carcinoma.