Irradiation activates cathepsin K (CSTK), nuclear factor of activated T-cells 5 (NFAT), Tartrate-Resistant Acid Phosphatase-5b (TRAP-5b), receptor activator of nuclear factor-kappa B ligand/Osteoprotegerin (Rank l/OPG), IL-1, IL-6, and TNFα genes in osteoclasts, induces inflammation and promotes osteoporosis [99]. The gene discussed is TNFRSF11B; the disease is osteoporosis.