Interleukin-6 family members, such as IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, have an important role in heart disease pathogenesis as they exhibit pro-inflammatory, anti-inflammatory, and proatherogenic effects using different trans-signaling pathways [115]. The gene discussed is LIF; the disease is heart disorder.