Interestingly, besides SSc, which is known to be characterized by peripheral microvascular dysfunction culminating in capillary loss not compensated by sufficient angiogenesis, alterations in NRP1 and Sema3E protein levels have also been reported in several types of cancer, a pathologic condition that is instead characterized by excessive angiogenesis [36,37,38,39,40,41,42,43]. The gene discussed is SEMA3E; the disease is systemic sclerosis.