As far as ischemic DUs are concerned, both sNRP1 and Sema3E were significantly lower in SSc patients with DUs (median 0.08 ng/mL, IQR 0.00–0.73 ng/mL for sNRP1 and median 0.22 ng/mL, IQR 0.00–0.54 ng/mL for Sema3E) with respect to those without DUs (median 2.18 ng/mL, IQR 0.62–3.21 ng/mL for sNRP1 and median 0.56 ng/mL, IQR 0.34–0.95 ng/mL for Sema3E; p < 0.001 for both molecules; Figure 4A,B). The gene discussed is SEMA3E; the disease is systemic sclerosis.