SEMA3E and systemic sclerosis: Since, when comparing SSc subgroup medians, we found significant differences in circulating sNRP1, Sema3E, and Slit2 according to the severity of the NVC pattern and the presence of ischemic DUs, we finally performed multiple logistic regression analysis combining the serum levels of the three molecules as independent variables, and one of the two abovementioned disease phenotypes as a single dependent variable each time.