When evaluating the possible association of sNRP1, Sema3E, and Slit2 with different SSc clinical phenotypes, none of the three circulating molecules was found to be significantly different according both to the SSc cutaneous subset (i.e., limited cutaneous SSc and diffuse cutaneous SSc) and to the distinct autoantibody pattern (data not shown). The gene discussed is SEMA3E; the disease is systemic sclerosis.