Circulating levels of sNRP1 were significantly decreased in SSc patients (median 1.39 ng/mL, IQR 0.14–2.82 ng/mL) compared to the healthy controls (median 2.52 ng/mL, IQR 0.68–5.36 ng/mL; p < 0.001; Figure 1A), while both serum Sema3E and Slit2 were found to be significantly increased in SSc with respect to the controls (median 0.48 ng/mL, IQR 0.19–0.80 ng/mL vs. median 0.23 ng/mL, IQR 0.00–0.37 ng/mL for Sema3E; median 9.97 ng/mL, IQR 7.97–14.44 ng/mL vs. median 8.75 ng/mL, IQR 6.22–11.25 ng/mL for Slit2; p < 0.001 for both molecules; Figure 1B,C). Here, SLIT2 is linked to systemic sclerosis.