In addition, for sNRP1, the ROC curve analysis revealed a cutoff value of 3.46 ng/mL, with 46.4% sensitivity and 92.8% specificity in discriminating between SSc patients and healthy controls, while the cutoff value for Sema3E was 0.43 ng/mL, with 58.4% sensitivity and 83.6% specificity. Here, SEMA3E is linked to systemic sclerosis.