In a previous published study [29], it was found that some motifs, such as Forkhead Box A1 (FOXA1) and Homeobox B13 (HOXB13), in AR malignant shift were more abundant in PCa than the normal prostate tissue, and this shift would further lead to the transcription of cancerous phenotype. This evidence concerns the gene FOXA1 and posterior cortical atrophy.