The most statistically significant underrepresented gene sets were related to the E2F pathway (Supplementary Figure S2), pediatric cancer markers, neoplastic transformation via the STAT3 pathway, MYC and TFRC targets, the cell cycle G2/M checkpoint, TNFA-signaling via NFKB, epithelial mesenchymal transition, the apoptosis process caused by CDKN1A via TP53 and neoplastic transformation KRAS signaling pathways (Supplementary Figure S3A,B). The gene discussed is TP53; the disease is cancer.