The strategy involved searching the databases using the following Medical Subject Heading (MeSH) terms: ‘breast cancer’, ‘invasive breast cancer’, ‘targeted therapy’, ‘cancer stages’, ‘cancer type’, ‘primary therapy’, ‘iron overload’, ‘iron chelator’, ‘deferoxamine’, ‘deferasirox’, ‘NF-κB’, and ‘ROS’. The gene discussed is NFKB1; the disease is breast cancer.