LEP and obesity due to melanocortin 4 receptor deficiency: They found that the obesity hormone leptin increases the expression of the cell adhesion molecule, intercellular adhesion molecule (ICAM-1), in the nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in a dependent manner in human-derived primary bronchial epithelial cells and the BASB-2B airway epithelial cell line in vitro [25].