Male sex, overweight, obesity, older age, smoking, alcohol consumption, moderate-to-severe OSAS, RLS alone or combined with PLMs, short sleep duration alone, comorbid insomnia disorder, type 2 diabetes, untreated hypertension, controlled hypertension, uncontrolled hypertension, dyslipidaemia without statin therapy, dyslipidaemia with statin therapy, cardiovascular comorbidities, aspirin therapy, and CRP levels ≥1 mg/L were significantly associated with moderate-to-high 10-year CVD risk in apnoeic individuals (Table 4). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.