The haplotype A-A-G of the TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), and TNF-238A/G (rs361525) polymorphisms were associated with the decreased odds of exudative AMD and the haplotype A-G-G with the increased odds of exudative AMD occurrence. Here, TNF is linked to age-related macular degeneration.