Due to the vital role of inflammatory molecules in the pathogenesis of AMD, we aimed to determine the associations of tumor necrosis factor-alpha (TNF-α) gene single-nucleotide polymorphisms (SNPs) TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-α serum concentration with AMD. Here, TNF is linked to age-related macular degeneration.