TNF and age-related macular degeneration: On the other hand, statistical analysis of exudative AMD have shown that haplotype A-A-G of TNF-α (rs1800630, rs1800629, and rs361525) is associated with the decreased odds of exudative AMD development (OR = 0.12; 95% CI: 0.05–1,29; p < 0.0001), and the haplotype A-G-G of TNF-α (rs1800630, rs1800629, and rs361525) is associated with increased odds of exudative AMD development (OR = 24.45; 95% CI: 9.39–63.63; p < 0.0001) (Table 5).