Incubation of whole blood samples from COVID-19 patients with LPS increased the CD45 expression on granulocytes from 36,252 ± 1113 to 93,807 ± 2012 (p < 0.0001) and on monocytes from 134,756 ± 3536 to 148,947 ± 3108 (p = 0.003), and reduced the expression on lymphocytes from 165,919 ± 2715 to 133,729 ± 2050 (p < 0.0001). The gene discussed is PTPRC; the disease is COVID-19.