CDH1 and neoplasm: In this process, which was subsequently described as mesenchymalization or stromalization, attributable to the activation of dormant mesenchymal genes in tumor epithelial cells [41], formerly polarized tumor epithelial cells lose cell adhesion molecules (E-cadherin) and secrete matrix [42,43] before separating and dispersing in the copious myxoid stroma, where they have been observed to simulate primitive mesenchyme or “swarming bees” and to express α5-integrin, Fibroblastic and chondrocyte collagens (types I–III) [44,45].