MYO5B and microvillus inclusion disease: To understand the role of SGK1 in MVID diarrhea, the current study generated tamoxifen-inducible cMYO5BKO and cMYO5B-SGK1 double knockout mouse models (cSGK1/MYO5B-DKO) to examine the impact of loss of MYO5B alone compared with loss of both SGK1 and MYO5B on severity of diarrhea, carbohydrate malabsorption and ion transporters in the intestines.