To understand the contribution of SGK1 to carbohydrate loss in MVID diarrhea, we examined fecal fluid volumes, fecal glucose concentration, and protein expression of SGLT1 and GLUT2 in small intestinal mucosal lysates from heterozygous, tamoxifen-treated cMYO5BKO or cSGK1-MYO5B DKO mice. Here, SGK1 is linked to microvillus inclusion disease.