A high-fat diet and obesity are associated with chronic low-grade systemic inflammation and can induce the secretion of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α, interleukin-1 (IL-1), and interferon gamma (IFN-γ) [24,25,26,27,28]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.