RTN4 and myeloid sarcoma: Moreover, previous studies revealed that RTN4 seems to be an important modulator of neuroinflammation in microglia/macrophages [36] and can inhibit neurite outgrowth and prevent the regeneration of severed axons [37]; both processes are also more potentiated in the later phase of disease, which may partially explain the lower accuracy of this biomarker in newly diagnosed patients with MS.