PGP and rhabdomyolysis: In addition, CsA acts as both an inhibitor and a substrate for permeability glycoprotein (P-gp) [125], which has as substrates atorvastatin, lovastatin, and pravastatin; for all the reasons mentioned above, concentrations of both immunosuppressants and statins (and consequently the risk of serious side effects such as statin rhabdomyolysis) may increase [126].