Medical therapies for women with adenomyosis include suppressive hormonal treatments, such as continuous use of oral contraceptive pills, high-dose progestins, selective estrogen receptor modulators, selective progesterone receptor modulators, the levonorgestrel-releasing intrauterine device, aromatase inhibitors, danazol and gonadotropin-releasing hormone agonist (GnRHa) [153,154]. The gene discussed is ESR1; the disease is adenomyosis.