Among the predisposing factors for the development of diabetes are severe CFTR mutations (80% of subjects with severe mutations develop CFRD after the age of 40 [19]), a family history of type 2 diabetes, systemic use of corticosteroids, organ transplantation, CF-related liver disease and the development of pancreatic insufficiency [20]. This evidence concerns the gene CFTR and cystic fibrosis-related diabetes.