For example, a patient after LT with an elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) above 5000 U/L, but with low or no vasopressor requirement, continuously decreasing lactate level, and preserved renal function, is far less concerning in comparison to a patient with a high vasopressor requirement, impaired lactate clearance, and who is developing renal failure. The gene discussed is GPT; the disease is Renal insufficiency.