SERPINE1 and chronic liver failure: The causes of hypercoagulability in ESLD are mostly related to endothelial dysfunction [74,75], with release of von Willebrand factor (vWF), factor VIII, and plasminogen activator inhibitor-1 [66,76,77,78] from the endothelium combined with a simultaneous decrease in hepatic production of ADAMRS13 (a cleaving protease regulating vWF) [79].