In our largest retrospective analysis to date, which included 1252 breast cancer patients (811 BRCA1 gene mutation carriers, 430 BRCA2 gene mutation carriers, and 11 BRCA1 and 2 gene mutation carriers), 195 patients became pregnant at least once and 150 of them gave birth for a total of 170 children. The gene discussed is BRCA1; the disease is breast cancer.