In an attempt to characterize severe asthma worldwide, additional data from the International Severe Asthma Registry showed that 50% of patients with severe asthma had high IgE levels (>150) and that IgE levels varied according to severity; patients receiving Global Initiative for Asthma step-five treatment had higher total IgE levels compared to those receiving step-four treatment [33]. The gene discussed is IGHE; the disease is asthma.