IRAK1 and neoplasm: Some of the targets of its encoded miRNAs are tumor necrosis factor, interleukin-1 receptor-associated kinase 1, leukocyte Transcripts of interleukin 1-β, TNF receptor-related factor 6, and complement factor H. Thus, low expression of hsa-mir-146a can cause tumor cells to be unrecognized causing immune evasion and reducing inflammatory responses [51].