Interestingly, by using a combination of SNaPshot assays, Sanger sequencing, and ddPCR, Chang et al. evaluated the presence of TERT , BRAF, and NRAS mts in paired primary and metastatic tumors from 60 patients and in multiple metastatic tumors from 39 patients whose primary tumors were unavailable [110]. This evidence concerns the gene NRAS and metastatic neoplasm.