NRAS-mutant melanomas are much more unpredictable and bear a worse prognosis when compared to melanomas driven by other RAS isoforms or BRAF-mutant melanomas [105]; however, a recent study potentiated that brain metastases emanating from thin and un-ulcerated tumors are enriched in KRAS mutations, occurring mainly in codons 12, 13 and 61 [107]. This evidence concerns the gene BRAF and melanoma.