ESR1 and breast cancer: This is not the first study to investigate building a nomogram to predict RS; from their series of 485 patients with ER+/HER2− breast cancer with 0–3 positive lymph nodes, Lee et al. developed a nomogram which demonstrated the ability of ER score, PgR score, tumor grade, lymphovascular invasion (LVI), and Ki-67 to predict low-risk RS (RS < 25) [42].