Specifically, anti-IL-5 (mepolizumab, reslizumab), anti-IL-5 receptor α (benralizumab), and prostaglandin D2 receptor antagonist (fevipiprant) reduce sputum eosinophilia, and the efficacy of IL-4 receptor (dupilumab) has already been proven [90,91,92,93]. This evidence concerns the gene IL5 and Increased total eosinophil count.