CYP3A4 and diabetes mellitus: The main finding of this study includes (1) CYP3A haplotype, particularly CYP3A4*1B + 3A5*3 + 3A5*6 allele combinations, which were a significant predictor of IR, IFG, and overall GMD, and (2) CYP2B6*6 is significantly associated with the risk of developing DM in EFV-based cART.