Therefore, to test the possibility of AgNPs as a potential therapeutic for MPNSTs, we evaluated the cytotoxicity of AgNPs in a panel of cell lines representing NF1-associated NF1-deficient MPNSTs (S462TY, ST-8814), sporadic NF1-wildtype MPNST (STS26T), and normal Schwann cells (iHSC-1λ, iHSC-2λ) as a normal cell control (Table 1). The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.