NF1 and neurofibromatosis type 1: Further investigations showed that AgNP-mediated cytotoxicity is dependent on the expression of neurofibromin, as the restoration of functional neurofibromin in NF1-associated MPNST cells decreased the sensitivity to AgNP, and the knockdown of neurofibromin increased the AgNP-mediated cytotoxicity of normal Schwann cells.