On the other hand, for metastatic/advanced UC cisplatin-unfit patients, two ICI drugs, Keytruda (Pembrolizumab) and Tecentriq (Atezolizumab), were approved by FDA and EMA as first-line therapy, but their use is restricted to patients harboring a PD-L1 positive tumor [63,64]. Here, CD274 is linked to neoplasm.