Molecules able to inhibit the PD-1/PD-L1 axis may restore immunological reaction against tumor cells, and, on this basis, in the last decade, several monoclonal antibodies targeting both PD-1 (as Pembrolizumab and Nivolumab) and PD-L1 (including Atezolizumab, Avelumab and Durvalumab) were developed [7,8]. This evidence concerns the gene CD274 and neoplasm.