In fact, these data suggest that CFH (1q31), ARMS2 (10q26.16), IL-8 (4q12-q13), TIMP3 (22q12.3), SLC16A8 (22q13.1), RAD51B (14q23), VEGFA (6p21.1), and COL8A1 (3q12.1) may contribute to the onset of wet AMD at different levels. The gene discussed is COL8A1; the disease is wet macular degeneration.