On this subject, a large-scale genotyping analysis including 1976 Italian subjects identified eight risk variants (rs1061170, T/C; rs10490924, G/T; rs2227306, C/T; rs5749482, C/G; rs8135665, C/T; rs8017304, A/G; rs943080, C/T; rs13081855, G/T) located within different genes (CFH, ARMS2, IL-8, TIMP3, SLC16A8, RAD51B, VEGFA, and COL8A1) known to be involved in the etiopathogenesis of wet AMD [5]. This evidence concerns the gene COL8A1 and wet macular degeneration.