ERBB2 and neoplasm: Thirdly, the extent of response to NAC, namely pCR, has a relevant prognostic role at the individual level, as confirmed by a meta-analysis including 11,955 patients from twelve clinical trials; a significant correlation between pCR and DFS (hazard ratio, 0.48; 95% CI, 0.43–0.54) and OS (hazard ratio, 0.36; 95% CI, 0.31–0.42) was reported in each tumor subtype (luminal A/B, HER2-positive, and triple-negative tumors), although the strength of association was higher for more aggressive subtypes (HER2-positive and triple-negative) [15].