Initially, the EASIX index was described by Luft et al. as a predictor of death in patients with acute graft versus host disease (GvHD) after allogeneic haematopoietic marrow cell transplantation it correlated well with the concentration of endothelial stress markers, particularly with CXCL-8/IL-18 and free IL-18 [25,26]. The gene discussed is IL18; the disease is acute graft versus host disease.