In this regard, the effect of relaxin-2 of inhibiting calcification and preserving elastin, together with its known roles in inhibiting vascular inflammation and the recruitment and adhesion of inflammatory cells to the endothelium, as well as mitigating chemokines, cytokines, and endothelial adhesion molecules expression at cardiac level, suggest the possible use of relaxin-2 as a biomarker and as a therapeutic strategy in situations of aortic valve stenosis [111,115,129,140,141,142]. This evidence concerns the gene RLN2 and aortic valve stenosis.