The disruption of the cyclophilin gene Bccyp2, an inhibitor of calcineurin, did not impair the pathogen mycelial growth, osmotic and oxidative stress adaptation or cell wall integrity but delayed conidial germination and germling development; altered conidial and sclerotial morphology and reduced infection cushion formation, sclerotial production and virulence [99]. Here, PPIB is linked to infection.